产品货号：
GS4666
中文名称：
重组人sTNF RII/TNFRSF1B
英文名称：
Recombinant Human soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 20.0kDa,a single non-glycosylated polypeptide chain containing 184 amino acids.
储存条件：冷冻（-20℃）
概述
Tumor Necrosis Factor Receptor-I(TNF RI,also known as p55/p60)and TNF RII(also known as p75/p80)are both high affinity receptors for TNF-alpha and -beta,potent mediators of multiple aspects of inflammatory immune responses.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B,respectively.Whereas all cell types are thought to express TNF RI,TNF RII expression is limited primarily to hematopoietic cells and cells of the immune system.Most of the biological functions of TNF are mediated via TNF RI.Soluble forms of both TNF RI and TNF RII,generated as a result of proteolytic cleavage of the extracellular domains,have been detected in vivo in various biological fluids.The soluble TNF receptors can bind TNF with high affinity and functions as TNF antagonists.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人sTNF RII/TNFRSF1B，sTNF RII/TNFRSF1B, Human
储存条件：冷冻（-20℃）
概述
Tumor Necrosis Factor Receptor-I(TNF RI,also known as p55/p60)and TNF RII(also known as p75/p80)are both high affinity receptors for TNF-alpha and -beta,potent mediators of multiple aspects of inflammatory immune responses.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B,respectively.Whereas all cell types are thought to express TNF RI,TNF RII expression is limited primarily to hematopoietic cells and cells of the immune system.Most of the biological functions of TNF are mediated via TNF RI.Soluble forms of both TNF RI and TNF RII,generated as a result of proteolytic cleavage of the extracellular domains,have been detected in vivo in various biological fluids.The soluble TNF receptors can bind TNF with high affinity and functions as TNF antagonists.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 0.2μg/ml,corresponding to a specific activity of>5000 IU/mg in the presence of 0.25ng/mL of rHuTNF-α. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4. |
| 内毒素 | Less than 0.1 EU/μg of rHusTNF RII/TNFRSF1B as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MPAQVAFTPY APEPGSTCRL REYYDQTAQM CCSKCSPGQH AKVFCTKTSD TVCDSCEDST YTQLWNWVPE CLSCGSRCSS DQVETQACTR EQNRICTCRP GWYCALSKQE GCRLCAPLRK CRPGFGVARP GTETSDVVCK PCAPGTFSNT TSSTDICRPH QICNVVAIPG NASMDAVCTS TSPT |
相关搜索：重组人sTNF RII/TNFRSF1B，sTNF RII/TNFRSF1B, Human